Frequently Asked Questions

Transdermal patches are adhesive patches worn on the skin that deliver active ingredients directly through the skin barrier and into the bloodstream. A concentration gradient drives the ingredients from the patch reservoir, through the dermis, and into the capillary network — providing slow, sustained absorption over 8–12 hours.

Oral supplements must survive stomach acid and the digestive tract before reaching the bloodstream, which degrades potency and can cause GI discomfort. Transdermal delivery bypasses the entire digestive system, providing a steadier, more consistent absorption curve — no spikes, no crashes, and no stomach upset.

Yes. Ingredients in Duori patches absorb directly through the skin and into circulation, completely bypassing the gastrointestinal tract and first-pass liver metabolism. This is particularly beneficial for ingredients like Berberine whose oral bioavailability is limited by digestive breakdown.

Duori patches are formulated for 8–12 hours of sustained delivery, depending on the formula. The release rate is controlled by the patch matrix — ingredients diffuse gradually and continuously rather than all at once, providing a smooth, even level of absorption throughout the wear period.

Apply to a clean, dry, hairless area of skin with good circulation — such as the inner wrist, upper arm, shoulder, upper back, or lower abdomen. Avoid areas with cuts, rashes, or broken skin. Clean and dry the site before application for best adhesion.

Most Duori patches are designed to be worn for 8–12 hours, then removed. For daytime formulas (Focus, Weight Loss, Gut Health), apply in the morning and remove before bed. For the Sleep Patch, apply 30–60 minutes before bedtime and remove when you wake up.

Rotate application sites daily. Applying repeatedly to the exact same spot can cause mild skin irritation or reduced adhesion. Alternate between left arm, right arm, upper back left, and upper back right — then repeat the cycle.

Yes. Duori patches are water-resistant and designed to stay adhered through sweat and exercise. Brief exposure to water — a shower or swim — is fine. For sleeping, the Sleep Patch is specifically designed for overnight wear. If a patch loosens at an edge during intense activity, press it back down or apply a small piece of medical tape over the edge.

Yes. Most Duori patches can be worn simultaneously on different skin sites. The formulas are targeted and do not overlap in active ingredients. Popular stacks include GLP-1 + NAD+ for daytime energy and metabolism, and Sleep + NAD+ for an evening wind-down. Always apply each patch to a separate location on the body.

Results vary by formula and individual. Most customers feel an effect from the Focus and Sleep patches within the first 1–3 uses. Metabolism and Weight Loss support benefits build over 2–4 weeks of consistent use. Skin and Beauty improvements from the Collagen Glow patch typically become noticeable after 4–8 weeks of daily use.

Consistency is the most important factor — daily use compounds over time. Skin hydration affects absorption rate; well-hydrated skin absorbs more efficiently. Application site matters too — vascular areas like the inner wrist or inner upper arm deliver faster uptake than thicker-skinned areas. Lifestyle factors including sleep quality, hydration, and diet also influence outcomes.

We recommend a minimum of 30 days of consistent daily use to evaluate results, and ideally 60–90 days for cumulative-benefit formulas like Collagen Glow and GLP-1 Support. That is exactly why all Duori patches come with a 60-day money-back guarantee — enough time to genuinely assess whether the formula is working for you.

Yes. Duori patches are dermatologist-tested for skin safety. Each formula is assessed for adhesion, skin irritation potential, and sensitization before release. Every production batch is also third-party lab tested for purity and potency.

Yes. All Duori patches are 100% vegan and cruelty-free. Our formulas use plant-derived ingredients, and no animal testing is conducted at any stage of development or production.

Yes. All Duori patches are stimulant-free. Our formulas contain no caffeine, ephedrine, synephrine, or any other stimulant compound. Energy and focus benefits come from adaptogenic herbs, nootropics, and B vitamins — not stimulants. You can use them daily without building tolerance or experiencing a crash.

Duori patches are formulated with a hypoallergenic medical-grade adhesive suitable for most skin types, including sensitive skin. We recommend patch-testing on a small area for the first few uses. If redness or irritation persists beyond 30 minutes after removal, discontinue use and consult a dermatologist.

Yes. If you are pregnant, breastfeeding, have a medical condition, or take prescription medications, please consult your healthcare provider before use. Transdermal delivery is highly efficient — ingredients reach the bloodstream directly — making physician review important in these cases.

Duori offers two sleep formulas. The Sleep Patch is melatonin-free and uses Valerian Root, Ashwagandha, Magnesium, and L-Theanine to support natural sleep without hormonal dependency. The Sleep+ Patch includes a low-dose melatonin alongside the same botanical blend for those who prefer melatonin-supported sleep.

No. Because the ingredients are released gradually through the skin over 8–10 hours rather than hitting all at once like a pill, most users wake feeling genuinely rested without morning grogginess. Simply remove the patch when you wake up to stop delivery.

Apply the sleep patch 30–60 minutes before your intended bedtime. This allows the initial wave of ingredients to relax the nervous system before you try to fall asleep. Apply to the inner wrist or upper arm on clean, dry skin.

Yes. The Neuro and NAD+ focus patches are completely stimulant-free. Focus and mental clarity come from nootropic compounds, adaptogens, and cellular energy support — not caffeine or other stimulants. You can wear them daily without building tolerance or experiencing a crash.

The Neuro Patch is a cognitive focus formula featuring nootropics and adaptogens like Lion's Mane, Bacopa, and Rhodiola for acute mental clarity and sustained focus. The NAD+ Patch supports cellular energy production at the mitochondrial level — better suited for overall energy, longevity support, and reducing brain fog from fatigue. Many customers stack both.

No. Duori's GLP-1 Support patch is a natural wellness supplement that supports healthy metabolism and appetite regulation — it is not a pharmaceutical GLP-1 agonist and does not replace prescription medications like semaglutide or tirzepatide. The patch uses plant-based ingredients like Berberine, Chromium Picolinate, and Garcinia Cambogia that may support metabolic health through natural pathways.

Apply the Weight Loss patch in the morning with your first meal. Wearing it during the day aligns delivery with your active metabolic hours and meal times, when appetite regulation and metabolic support are most relevant. Remove after 8–10 hours.

The Duori Gut Health patches work systemically. Ingredients like Ginger, Peppermint, L-Glutamine, and Turmeric absorb through the skin into the bloodstream and support gut motility, inflammation, and the gut-brain axis. This is a complementary approach to probiotic foods or oral digestive enzymes, not a replacement.

The Digestion Patch targets immediate digestive comfort — bloating, discomfort after meals, and gut motility — using ingredients like Ginger Root, Peppermint, and Fennel. The Flora Patch is designed for long-term microbiome support using prebiotic and gut-balancing compounds. Many customers use the Digestion Patch as needed and the Flora Patch daily for ongoing gut health maintenance.

The Collagen Glow patch delivers collagen precursors and skin-supportive ingredients transdermally, bypassing digestive breakdown that can degrade oral collagen peptides before they reach target tissues. The formula is also entirely vegan — using Vitamin C, Biotin, and plant-derived hyaluronic acid precursors rather than animal-derived collagen, making it a great option for those who prefer plant-based beauty support.

Each Duori patch pack contains 30 patches — a full 30-day supply for daily use.

Duori offers free shipping on all orders over $30. All patches also come with a 60-day money-back guarantee — if you are not satisfied, contact us at hello@duoripatches.com.