60- DAYS MONEY BACK GUARANTEED

BUY 2, GET 1 FREE

How Do Transdermal
Patches Actually Work?

Patches deliver active ingredients straight through your skin into the bloodstream — no digestion, no waste, just faster absorption.

Shop All Patches → See the Science ↓
The Basics

What Is Transdermal Delivery?

Active ingredients absorbed through the skin, straight into your bloodstream — no pills, no digestion, no waste.

Duori transdermal patch

Transdermal delivery sends active ingredients through your skin and into your bloodstream — no pills, no digestion required.

Ingredients cross three skin layers to reach your blood, avoiding the stomach and first-pass liver metabolism, which can destroy up to 80% of an oral supplement before it ever works.

Step by Step

How Patches Deliver Ingredients

From application to absorption, in four simple steps.

Apply

Place on Skin

Apply to clean, dry skin. The adhesive holds ingredients ready for delivery.

Penetrate

Cross the Barrier

Ingredients gradually cross the stratum corneum, your skin's outer barrier.

Absorb

Enter the Bloodstream

Capillaries in the dermis absorb ingredients directly into your blood.

Deliver

Sustained Release

A steady stream over 8–12 hours — no spikes, no crashes.

The Advantage

Why Transdermal Beats Oral

Your digestive system destroys most of what you swallow before it can work.

Better Absorption

Pills must survive stomach acid and enzymes. Patches skip the GI tract entirely.

Sustained Release

Pills spike and crash. Patches deliver steady doses over 8–12 hours.

Higher Bioavailability

Up to 80% of a swallowed supplement is lost to liver metabolism. Patches avoid this.

Our Technology

What Makes Duori Different

Advanced adhesive, optimized formulas, and rigorous testing.

Advanced Adhesive Matrix

Medical-grade, hypoallergenic adhesive keeps patches secure for 8–12 hours of steady release.

Optimized Formulations

Every formula is built for skin absorption — not repackaged pill ingredients.

Quality & Testing

Dermatologist-tested, vegan, non-GMO, and GMP-manufactured. Every batch is tested.

How We Compare

Patches vs. Oral Supplements

How transdermal stacks up against pills, capsules, and powders.

Feature
Transdermal Patch
Capsules / Pills
Powders / Drinks
Bioavailability
Up to 95%
10–20%
20–30%
Delivery duration
8–12 hours
1–3 hours
1–2 hours
Bypasses digestion
Yes
No
No
First-pass metabolism
Avoided
Full exposure
Full exposure
Sustained release
Continuous
Spike & crash
Spike & crash
Daily compliance
Peel & apply
Multiple doses
Mixing required
GI side effects
None
Common
Possible
Vegan & clean label
Yes (Duori)
Varies
Often no
Common Questions

Transdermal Patch Science FAQ

Quick answers on how transdermal patches work.

Transdermal means "through the skin" — delivering ingredients across the skin barrier and directly into the bloodstream, bypassing digestion entirely. It's been used in medicine for decades.
An adhesive matrix holds active ingredients, which gradually permeate the stratum corneum, epidermis, and dermis, where capillaries absorb them into the blood — continuously over 8–12 hours.
Bioavailability is the percentage of an ingredient that actually reaches your bloodstream active. Oral supplements can lose 50–80% to digestion. Transdermal delivery avoids most of that loss.
Pills must survive stomach acid, enzymes, and liver metabolism before reaching your blood. Patches skip all of that by delivering straight through the skin.
Most patches begin delivering within 30–60 minutes, then continue steadily for 8–12 hours — no spike, no crash.
Yes — transdermal delivery is well-established in medicine (nicotine, pain relief, and hormone patches). Duori's patches are dermatologist-tested and vegan. Consult your provider for specific concerns.
Apply to clean, dry, hairless skin — wrist, upper arm, shoulder, or lower back work well. Rotate sites daily and avoid irritated or broken skin.
Yes. Many customers combine patches on different areas — for example, Neuro + NAD+ for cognitive support, or Sleep + Collagen for overnight recovery.

Experience the
Science of Better Delivery

Science-backed, plant-powered patches designed for real results.

Shop All Patches →
60-day money-back guarantee
Free shipping
Free gifts + 20% Off on subscription
Vegan & cruelty-free